Prof. Mehmet Haberal is presented with The Award of The Spanish Order of The Civil Merit (Cruz de Official) by His Majesty King Felipe VI, King of Spain.
We are honored to announce that Prof. Dr. Seza Özen who is the member of Honorary Advisory Board of JBACHS has already won the Aziz Sancar Science Award of TUSEB.
We are happy to announce that The Journal of Basic and Clinical Health Sciences (JBACHS) is indexed by the Emerging Sources Citation Index since November 2017, and indexed by the Ulakbim-TR since 2017.
Journal of Basic and Clinical Health Sciences 2020 , Vol 4 , Issue 3
Hydroxychloroquine: From Pharmacological Profile to Neglected Adverse Reactions
Sevgi Akarsu1
1Dokuz Eylül University, Faculy of Medicine, Department of Dermatology, İzmir, Turkey DOI : 10.30621/jbachs.2020.1165 The effectiveness of hydroxychloroquine (HCQ) has been increasingly recognized in nearly all major fields of medicine. This ancient but still indispensable drug has a high bioavailability and a very long half-life due to its large volume of distribution. Although HCQ is generally considered a safe and well-tolerated drug, it can sometimes cause mild and reversible reactions that do not require treatment interruption such as gastrointestinal discomfort, photosensitivity and cutaneous findings. However, long-term treatment and high cumulative doses of HCQ may rarely lead to severe adverse reactions (including retinal, neuromuscular, cardiac and auditory toxicities) which are considered serious and require drug discontinuation but unfortunately not always reversible. The interaction of HCQ with other drugs (and vice versa) is also an important clinical issue. It has been emphasized that caution should be used in prescribing medications concurrently with HCQ, such as drugs that prolong QT interval and other arrhythmogenic drugs, drugs known to induce retinal toxicity, insulin or other antidiabetics, digoxin, cyclosporine, drugs used to treat myasthenia gravis and drugs known to lower the convulsive threshold. In this article, the pharmacological properties, clinically significant drug interactions as well as frequent and rare adverse reactions of HCQ have been reviewed in detail. Keywords : hydroxychloroquine, antimalarial, pharmacokinetic, drug interaction, adverse reaction