Prof. Mehmet Haberal is presented with The Award of The Spanish Order of The Civil Merit (Cruz de Official) by His Majesty King Felipe VI, King of Spain.
We are honored to announce that Prof. Dr. Seza Özen who is the member of Honorary Advisory Board of JBACHS has already won the Aziz Sancar Science Award of TUSEB.
We are happy to announce that The Journal of Basic and Clinical Health Sciences (JBACHS) is indexed by the Emerging Sources Citation Index since November 2017, and indexed by the Ulakbim-TR since 2017.
Journal of Basic and Clinical Health Sciences 2020 , Vol 4 , Issue 3
Serum Fetuin A and Secreted Phosphoprotein 24 as Diagnostic Markers in Inflammatory Bowel Disease
Inanc Karakoyun1,Ferruh Kemal Isman2,Banu Isbilen Basok1,Fatma Demet Arslan1,Bulent Calik3,Nevin Genc Kahraman2,Gokhan Akbulut3,Celal Ulasoglu4
1University of Health Sciences, Tepecik Training and Research Hospital, Department of Medical Biochemistry, Izmir, Turkey
2Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Medical Biochemistry, Istanbul, Turkey
3University of Health Sciences, Tepecik Training and Research Hospital, Department of General Surgery, Izmir, Turkey
4Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Gastroenterology, Istanbul, Turkey
DOI : 10.30621/jbachs.2020.1123 Purpose: A completely satisfactory biomarker has yet to be identified for the diagnosis and characterization of inflammatory bowel disease (IBD). This study evaluated the utility of fetuin A and secreted phosphoprotein 24 kDa (Spp24) as novel biomarkers in IBD.

Methods: Ninety IBD patients, 54 with ulcerative colitis (UC) and 36 with Crohn"s disease (CD), and 41 healthy controls (HC) were included. Serum fetuin A, Spp24, TNF-α, and IFN-γ levels were analyzed by ELISA. Serum C-reactive protein (CRP) levels were determined turbidimetrically by an automated procedure.

Results: There were no significant differences in serum Spp24 levels among the UC (17.15 pg/mL, mean), CD (18.88 pg/mL), and HC (14.77 pg/mL) groups (P>0.05). Median fetuin A levels were significantly lower in the UC (249 mg/L) and CD (254 mg/L) groups compared to HC (352 mg/L) (UC vs. HC P<0.001, CD vs. HC P<0.001). Fetuin A levels were not associated with disease activity, extent, or localization in UC or CD. In ROC curve analysis, a fetuin A cut-off value of 304 mg/L predicted IBD with better area under curve, sensitivity, and specificity (0.770, 76.1%, and 70.0%, respectively) compared to CRP (0.645, 32.2%, and 90.2%, respectively). TNF-α levels in IBD patients were not differ compared to HC (P>0.05), whereas IFN-γ levels were statistically significant between UC (3.94 pg/mL, median) and HC (2.65 pg/mL) groups (P=0.037).

Conclusion: Fetuin A may have an anti-inflammatory function in IBD and may be used as a potential biomarker for the discrimination of IBD patients from healthy individuals. Keywords : Fetuin A, inflammatory bowel disease, secreted phosphoprotein 24