Prof. Mehmet Haberal is presented with The Award of The Spanish Order of The Civil Merit (Cruz de Official) by His Majesty King Felipe VI, King of Spain.
We are honored to announce that Prof. Dr. Seza Özen who is the member of Honorary Advisory Board of JBACHS has already won the Aziz Sancar Science Award of TUSEB.
We are happy to announce that The Journal of Basic and Clinical Health Sciences (JBACHS) is indexed by the Emerging Sources Citation Index since November 2017, and indexed by the Ulakbim-TR since 2017.
Journal of Basic and Clinical Health Sciences 2020 , Vol 4 , Issue 3
Personalized Tumor Growth Prediction Using Multiscale Modeling
Serbulent Unsal1,Aybar Acar3,Mehmet Itik7,Ayse Kabatas5,Oznur Gedikli4,Feyyaz Ozdemir6,Kemal Turhan1
1Karadeniz Technical University, Biostatistics and Medical Informatics, Trabzon, Turkey
2Middle East Technical University, Health Informatics, Ankara, Turkey
3Middle East Technical University, Cancer Systems Biology Laboratory, Ankara, Turkey
4Karadeniz Technical University, Physiology, Trabzon, Turkey
5Karadeniz Technical University, Mathematics, Trabzon, Turkey
6Karadeniz Technical University, Medical Oncology, Trabzon, Turkey
7Izmir Democracy University, Mechanical Engineering, İzmir, Turkey
DOI : 10.30621/jbachs.2020.1245 Purpose: Cancer is one of the most complex phenomena in biology and medicine. Extensive attempts have been made to work around this complexity. In this study, we try to take a selective approach; not modeling each particular facet in detail but rather only the pertinent and essential parts of the tumor system are simulated and followed by optimization, revealing specific traits. This leads us to a pellucid personalized model which is noteworthy as it closely approximates existing experimental results.

Methods: In the present study, a hybrid modeling approach which consists of cellular automata for discrete cell state representation and diffusion equations to calculate distribution of relevant substances in the tumor microenvironment is favored. Moreover, naive Bayesian decision making with weighted stochastic equations and a Bayesian network to model the temporal order of mutations is presented. The model is personalized according to the evidence using Markov Chain Monte Carlo. To validate the tumor model, a data set belonging to the A549 cell line is used. The data represents the growth of a tumor for 30 days. We optimize the coefficients of the stochastic decision-making equations using the first half of the timeline.

Results: Simulation results of the developed model are promising with their low error margin (all correlation coefficients are over 0.8 under different microenvironment conditions) and simulated growth data is in line with laboratory results (r=0.97, p<0.01).

Conclusions: Our approach of using simulated annealing for parameter estimation and the subsequent validation of the prediction with invitro tumor growth data are, to our knowledge, is novel. Keywords : neoplasms, patient-specific modeling, adenocarcinoma of lung, precision medicine