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Journal of Basic and Clinical Health Sciences 2019 , Vol 3 , Issue 2
Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children with Asthma
Esra Akyüz Özkan1,Ayşe Yeşim Göçmen3,Yusuf Küçükbağrıaçık2,Melike Akyüz1
1University of Bozok School of Medicine, Department of Pediatrics, pediatrics, yozgat, Turkey
2University of Gazi School of Medicine, Department of Biophysics, Biophysics, ankara, Turkey
3University of Bozok School of Medicine, Department of Biochemistry, Biochemistry, yozgat, Turkey
DOI : 10.30621/jbachs.2019.580 Purpose: The aim of this study was to detect serum levels of trace elements, vitamin D and oxidant status in asthmatic children and to understand whether these elements reduce the number of attacks or use them as supplementation.

Methods:Fifty children with asthma and 50 healthy children were included in the study. We studied serum levels of vitamin D, selenium (Se), manganese (Mn), chromium (Cr), chlorine (Cl), iron (Fe), calcium (Ca), zinc (Zn), sodium (Na), magnesium (Mg), potassium (K), copper (Cu), total antioxidant capacity (TAS), total oxidative status (TOS) and oxidative stress index (OSI) in both group.

Results: In asthmatic group, the serum level of Cr, Se, Zn and TAS levels were lower (p=0.040, p=0.000, p=0.000, p=0.000 respectively) and serum Cu, TOS and OSI levels were higher than controls (p=0.000, p=0.000, p=0.000 respectively). Serum TAS level showed negative correlation with TOS, OSI, Fe, Cu, Mn, Se, Zn and positive correlation with Se and Vitamin D.

Conclusion: The supplementation of Se, Zn and Cr may provide better control of attacks and can be use treatment of asthma in children and modulating plasma antioxidants may have a beneficial effect on asthma progression. Keywords : Childhood asthma, trace elements, vitamin D, oxidative status