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Journal of Basic and Clinical Health Sciences 2019 , Vol 3 , Issue 2
The Effect of Mitochondrial DNA Mutations in Brain Tumors
Zübeyde Erbayraktar1,Zeynep Haşimoğlu1,R. Serhat Erbayraktar2
1Dokuz Eylül University, Health Sciences Institute, Biochemistry, İzmir, Turkey
2Dokuz Eylul University Faculty of Medicine, Neurosurgery, İzmir, Turkey
DOI : 10.30621/jbachs.2019.590 Purpose: Brain tumors are a group of diseases in which different genotypes result in different phenotypes at the molecular level. Although there have been a number of studies related to the role of alterations in nuclear genes, such as oncogenes and tumor suppressor genes, in the development of brain tumors, the effects of mitochondrial genes on tumorigenesis have not been well elucidated.

Methods: It is thought that mitochondrial DNA plays an important role in the tumorogenesis process due to the fact that it is more susceptible to mutations than the nuclear DNA and the repair mechanisms are weaker. Mitochondrial DNA mutations have been extensively studied for their use as biomarkers since they can reach high copy number in clonal characterization.

Results: MtDNA mutations play an important role in cancer developmental stages, but the mechanisms of cancer development and progression of these mutations are not fully explained.

Conclusion: The identification of mitochondrial DNA defects is anticipated earlier in the diagnosis of brain tumors, and more effective treatment protocols will be regulated. Keywords : Brain tumor, mitochondrial DNA, tumorigenesis