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Journal of Basic and Clinical Health Sciences 2019 , Vol 3 , Issue 2
New Insight of Tumor Microenvironment in Non-Small Cell Lung Cancer
Tolga Sever1,Asim Leblebici1,Altug Koc1,2,Cilem Binicier1,Aybüke Olgun1,3,Deniz Tuna Edizer1,4,Taha Resid Özdemir5,6,Gürdeniz Serin5,7,Melek Erdem5,8,Yasemin Basbinar9
1Dokuz Eylul University, Institute of Health Sciences, Department of Oncology, Translational Oncology, Izmir, Turkey
2Dokuz Eylul University, Faculty of Medicine, Medical Genetics, Izmir, Turkey
3Izmir Tepecik Training and Research Hospital, Internal Medicine, Izmir, Turkey
4Bozyaka Training and Research Hospital, Department of Ear Nose and Throat, Izmir, Turkey
5Dokuz Eylul University, Institute of Health Sciences, Department of Oncology, Basic Oncology, Izmir, Turkey
6Izmir Tepecik Training and Research Hospital, Genetic Diagnostic Center, Izmir, Turkey
7Ege University, Faculty of Medicine, Pathology, Izmir, Turkey
8Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Pediatric Hematology and Oncology, Izmir, Turkey
9Dokuz Eylul University, Institute of Oncology, Department of Translational Oncology, Izmir, Turkey
DOI : 10.30621/jbachs.2019.625 As in all living cells, cancer cells are evaluating is very important in the frames of tumor development and treatment. As in all evolutionary process, the environment of living cells has an important role. Tumor cells have an environment is called tumor microenvironment, affects the therapeutic response and clinical results. Tumor microenvironments involve various cell types, extracellular matrix substances that are in the niche of cancer cells. The microenvironment is not only important in tumorigenesis but it is effective on therapeutic efficacy. In this review, we carried out the interaction between non-small cell lung cancer and its microenvironment to point out the significance of the tumor environment. Keywords : Tumor Microenvironment, Non-Small Cell Lung Cancer, Extracellular Matris