We are happy to announce that The Journal of Basic and Clinical Health Sciences (JBACHS) is indexed by the Emerging Sources Citation Index since November 2017, and indexed by the Ulakbim-TR since 2017.
Journal of Basic and Clinical Health Sciences 2019 , Vol 3 , Issue 3
Antimicrobial Effect of Piceatannol, a Resveratrol Metabolite, on Staphylococcus Aureus
Nevcivan Güldaş1,Tuğba Uysal2,Hülya Ellidokuz3,Yasemin Başbınar4
1Dokuz Eylul University, Faculty of Medicine, Research Laboratory, Izmir, Turkey
2Dokuz Eylul University, Institute of Oncology, Department of Basic Oncology, Izmir, Turkey
3Dokuz Eylul University, Faculty of Medicine, Department of Biostatistics and Medical Informatics, Izmir, Turkey
4Dokuz Eylul University, Institute of Oncology, Translational Oncology Department, Izmir, Turkey
DOI : 10.30621/jbachs.2019.745 Objectives: Staphylococcus aureus (S. aureus) is one of the major human pathogens in both community acquired and nosocomial infections. Heavy increase of antibiotic resistance between S. aureus strains became an important public health problem in progress of time. In this study, the antimicrobial effects of piceatannol on S. aureus growth was investigated.

Patients and Methods: The antimicrobial effect of piceatannol on a standard S. aureus (DSMZ 6148) strain and two clinical S. aureus strains (C1 and C2) was tested in vitro at concentrations between 0 and 750 μg/ mL. Tigecycline and gentamicin were used as positive controls. For each strain, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values of piceatannol and the control antibiotics were determined separately using the broth microdilution method according to CLSI (Clinical and Laboratory Standards Institute) standards at 24 and 48 h.

Results: After 24 and 48 h of treatment with piceatannol, the average MIC for all tested strains was 283 μg/mL and 383 μg/mL, respectively. Bactericidal activity increased as piceatannol concentration increased for one of the three strains. After 24 and 48 h of treatment with piceatannol, the average MBC for all strains was 717 μg/ mL and 583 μg/ mL, respectively. The S. aureus strains were found to be susceptible to tigecycline and gentamicin.

Conclusion: Piceatannol has antimicrobial effect against S. aureus; however, more data regarding the effects of this compound on other microorganisms and its bioavailability are needed. Keywords : Piceatannol, Staphylococcus aureus, antimicrobial effect