We are honored to announce that Prof. Dr. Seza Özen who is the member of Honorary Advisory Board of JBACHS has already won the Aziz Sancar Science Award of TUSEB.
We are happy to announce that The Journal of Basic and Clinical Health Sciences (JBACHS) is indexed by the Emerging Sources Citation Index since November 2017, and indexed by the Ulakbim-TR since 2017.
Journal of Basic and Clinical Health Sciences 2020 , Vol 4 , Issue 1
Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?
Selma Tekin1,Esin Avcı2,Rukiye Nar2,Eylem Değirmenci1,Süleyman Demir2,Hande Şenol3
1University of Pamukkale School of Medicine, Department of Neurology, Denizli, Turkey
2University of Pamukkale School of Medicine, Department of Biochemistry, Denizli, Turkey
3University of Pamukkale School of Medicine, Department of Biostatistics, Denizli, Turkey
DOI : 10.30621/jbachs.2020.837 Background: We investigated the association of monocyte to high-density lipoprotein cholesterol (HDL) ratio (MHR), neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) with prognostic value and infarct types in patients with acute ischemic cerebrovascular disease (CVD).

Matherial and Methods: The study was carried out retrospectively in 223 patients, but after the exclusion criterion, 150 patients with acute ischemic CVD were included to the study. The complete blood count and lipid profile were examined at the admission of the patients. For initial neurologic status, National Institutes of Health Stroke Scale (NIHSS) score and for following-up, modified Rankin Scale (mRS) score were evaluated. After the etiological investigations and neuroimaging, infarct types were defined.

Results: We found that as the NIHSS score increased, LMR values decreased and NLR values increased statistically (p=0.02, p=0.013). Additionally, statistical significant differences were determined between MHR values and mRS scores (p=0.045). According to the results of regression analysis, it was observed that the increase of MHR was statistically significant on the MRS of people with cardioembolic infarction (p=0.004, StB=0.383).

Conclusion: Our study provides, LMR and NLR values are related with the initial neurologic state, and they would be prognostic markers for the neurological deficit of acute cerebrovascular disease. MHR can be a follow-up marker for CVD and also a predictable marker for cardioembolic infarct type. Keywords : Acute ischemic cerebrovascular disease, monocyte to high-density lipoprotein cholesterol ratio, neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, prognosis