Prof. Mehmet Haberal is presented with The Award of The Spanish Order of The Civil Merit (Cruz de Official) by His Majesty King Felipe VI, King of Spain.
We are honored to announce that Prof. Dr. Seza Özen who is the member of Honorary Advisory Board of JBACHS has already won the Aziz Sancar Science Award of TUSEB.
We are happy to announce that The Journal of Basic and Clinical Health Sciences (JBACHS) is indexed by the Emerging Sources Citation Index since November 2017, and indexed by the Ulakbim-TR since 2017.
Journal of Basic and Clinical Health Sciences 2020 , Vol 4 , Issue 1
Salivary Pro-Inflammatory Cytokines and Salivary Bacterial Challenge Effect on Dental Caries: A Clinico-Molecular Cross-Sectional Study
Ahu Pakdemirli2,Gizem Çalıbaşı Kocal3,Gülser Kılınç5,Ezgi Daşkın4,Hande Kemaloğlu1,Yasemin Başbınar4,Hülya Ellidokuz6
1Ege University, Faculty of Dentistry, Izmir, Turkey
2Equal First Author Dokuz Eylul University, Department of First and Emergency Aid, Izmir, Turkey
3Equal First Author Dokuz Eylul University, Department of Translational Oncology, Izmir, Turkey
4Dokuz Eylul University, Department of Translational Oncology, Izmir, Turkey
5Dokuz Eylul University, Department of Oral and Dental Health, Izmir, Turkey
6Dokuz Eylul University, Department of Biostatistics and Medical Informatics, Izmir, Turkey
DOI : 10.30621/jbachs.2020.920 Objectives: Objective of this study is to determine the correlation between salivary cytokine concentrations and cariogram value high (C1) and low (C2) experience in people. In this direction, saliva cytokines showed a significant correlation with the patient"s caries experience.

Patients and Methods: Unstimulated whole saliva samples were collected from 38 appropriate populations of patients aged between 20 to 57 years old. All patients" DMF (decay/missing/filled) values were higher than 0. Twenty-one caries activity groups (C1) and 17 caries nonactivity groups (C2) patients were collected for this study. Procedures of the clinical evaluation were the collection of saliva samples and oral examination. The whole saliva from 38 patients with C1 and C2 was investigated for the existence of GM-CSF, TNFα, IFN-g, IL-2, IL-4, IL-6, IL-8, and IL-10.

Results: The study population consisted of 38 subjects with a mean age of 34.76±14.43 years. Likewise, there was a significant interaction between salivary flow rate, S. Mutans number, number of Lactobacillus, number of meals and IL-6, a significant difference in caries activity groups.

Conclusion: Salivary cytokines demonstrated significant interactions to caries experience of the patient. Keywords : Salivary, Streptococcus mutans, Pro-inflammatory cytokines, Dental caries